Pharmacology Education Project

I

i.a.

i.a. refers to drug administration via the intra-arterial route.

i.c.

i.c. refers to drug administration via the intracerebral route.

i.c.v.

i.c.v. refers to drug administration via the intracerebroventricular route.

i.d.

i.d. refers to drug administration via the intradermal route.

i.g.

i.g. refers to drug administration via the intragastric route.

i.m.

i.m. refers to drug administration via the intramuscular route.

i.p.

i.p. refers to drug administration via the intraperitoneal route.

i.t.

i.t. refers to drug administration via the intrathecal route.

i.v.

i.v. refers to drug administration via the intravenous route.

IC50

IC₅₀ defines the molar concentration of an agonist or antagonist which produces 50% of its maximum possible inhibition in a functional assay. In a radioligand binding assay, IC₅₀ defines the molar concentration of competing ligand which reduces the specific binding of a radioligand by 50%.

ID50

ID₅₀ defines the dose of a drug that causes 50% of the maximum possible inhibition for that drug in vitro or in vivo.

immunopharmacology

Immunopharmacology is the branch of pharmacology concerned with the application of immunological techniques and theory to the study of the effects of drugs especially on the immune system.

imprint disorder

An abnormal state resulting from the process of genetic imprinting in which a gene is not transcribed due to an epigenetic modification such as methylation.

in vitro

In vitro refers to experiments taking place in a test-tube, culture dish or elsewhere outside a living organism.

in vivo

In vivo refers to experiments or assessments being made in a living organism.

insufflation

Insufflation in medical terms is a route of drug administration used for many respiratory drugs, such as emphysema, asthma and allergy medications. It is the act of inhaling a gas, powder or vapor in to the body. Nasal insufflation (= nasal administration) is becoming more widely used to administer certain types of drugs to children, and patients with a needle aversion e.g. nasal administration of influenza inoculation, although this method more correctly sprays the vaccine in to the nasal cavity, rather than the patient actively inhaling it.