There is only one nervous system, but for ease of description it is traditionally divided into the central nervous system (CNS) comprising the brain and spinal cord and peripheral nervous system (PNS) that conveys information from the CNS to the organs and tissues of the body and vice versa. By convention, those neurone cell bodies and their associated axons (or fibres) that conduct action potentials from the CNS to the periphery are termed efferents, whereas those that relay information in the opposite direction are known as afferents. Broadly, efferents send command signals directed towards the effectors of the body, such as muscles (skeletal, cardiac and smooth) and exocrine and endocrine glands.
The afferents and associated structures act as sensors of the internal and external environments, constantly providing the information essential to maintain homeostasis by the modulation of appropriate efferents. The autonomic nervous system (ANS) influences the activity of many body systems including digestion, respiration and circulation. Information about the internal and external environments is fed via afferent nerves to regions in the hypothalamus and the medulla, which control the activity of the autonomic nerves supplying the internal organs such as the heart, the blood vessels, the gastrointestinal system, lungs, endocrine and exocrine glands. At a relatively simply level, such regulation occurs via a reflex arc, typically polysynaptic, that often, but not invariably, involves the CNS. Numerous activities of the gut, such as peristalsis, are important examples of reflex control mediated by microcircuits that are independent of CNS participation. More generally a physiological variable, such as arterial blood pressure, is: (i) detected by sensory afferents; (ii) compared with a desired set point by a comparator within a co-ordinating centre of the the CNS and (iii) any deviation between the set point and measured variable (an error) is then minimised by adjustment of the activity of the efferents supplying the effector organs controlling that variable (e.g. heart rate and force of contraction, resistance of arterioles to blood flow) (Figure 1). A multitude of physiological processes are regulated by negative feedback, as exemplified in the neuronal control of arterial blood pressure mentioned above.
Moreover, an array of ‘mundane, or house-keeping’, activities that are indispensable to life occurs without conscious awareness (e.g. when asleep). Such constant, subconscious, monitoring and corrective action is one of the fundamental tasks of the autonomic (‘self-regulating’) nervous system (ANS).
What is the ANS? How is it defined?
John Newport Langley (1921), in a classic text (‘The Autonomic Nervous System’), summarised the ANS in a way that is rather difficult to improve upon, without resorting to ‘nit-picking’ with the benefit of hindsight:
‘’The autonomic nervous system consists of nerve cells and nerve fibres, by means of which efferent impulses pass to tissues other than multi-nuclear striated muscle.’’
Langley’s definition, in the clearest of terms, emphasises the vast territory of autonomic control: it is the CNS motor output to the whole body, other than skeletal, otherwise termed voluntary (multi-nuclear striated) muscle, the latter being innervated directly by efferent motor fibres termed α- and g- motor neurons (or motoneurons) that are part of the somatic nervous system. Langley’s (1921) definition does not include sensory (afferent) fibres that innervate the blood vessels and hollow organs (viscera) of the body. Although essential to autonomic control (such as the regulation of arterial blood pressure touched upon above), there has been considerable debate about whether all such afferents should properly be regarded as components of the ANS (a complexity clearly appreciated by Langley). For example, the activity of some visceral afferents that are nociceptive in function can undoubtedly evoke intense awareness (the pain of cardiac ischaemia being a prime example). For our purposes, we will ignore what for students might seem the largely distracting (and confusing!) semantics and simply appreciate the vital role of afferent input in autonomic control, whether arising from the viscera, or elsewhere. Indeed, ‘sensory’ input can be non-neuronal, as exemplified by numerous inflammatory mediators that influence autonomic output.
The ANS comprises both CNS and peripheral components. Within the brain, higher level autonomic control primarily involves cortical areas and subcortical nuclei of the hypothalamus and brainstem that will not, with the exception of the latter, be discussed in detail here. Functions essential to human health and life that are regulated by the ANS include:
- contraction and relaxation of vascular and visceral smooth muscle, thus affecting mechanical activity in virtually all of the systems of the body (e.g. cardiovascular, gastrointestinal, respiratory, reproductive, urinary)
- the heartbeat (e.g. cardiac rate, force and electrical activity)
- all exocrine gland secretions (e.g. lacrimation, sweating, gastric acid, exocrine pancreas) and many endocrine secretions (e.g. endocrine pancreas, adrenal medulla, liver)
- all aspects of metabolism (e.g. in the liver, skeletal muscle, adipose tissue)
- modulation of the function of immune organs and cells (e.g. mast cells, lymph nodes)
The pioneering studies of the motor ANS conducted over a century ago divided it in to two, or three, subdivisions:
- sympathetic (the fright, fight and flight system)
- parasympathetic (the rest and digest system)
- (although it can be argued that this ‘little brain of the gut’, comprising more than 100 million neurones in man, is separate from the ANS). This might be justified by the fact that many activities of the gut do not require extrinsic neuronal input for their co-ordination and execution.
As described in other sections, there is a firm anatomical and also functional rationale to such a classification but there has been an unfortunate tendency to extend this to a parody, or polarisation, of function. Thus, it is common to read that the sympathetic division (originally named because it acts ‘in sympathy’ with the emotions) is the mediator of ‘fight, or flight’ reactions when the organism is confronted with danger, or other extremely stressful situation (a Pharmacology exam?). The parasympathetic division is often associated with ‘rest, or digest’ activities (or plain idleness!). A further extension is that the sympathetic and parasympathetic divisions are physiological opponents with one, or the other, dominant in particular situations. Generally, this is quite misleading (a simple objection being that many organs are not innervated by both sympathetic and parasympathetic fibres) as we will explore in sections devoted to the sympathetic and parasympathetic divisions of the ANS. For now, note that whilst sub-divisions are convenient ‘labels’ for ease of description, there is functionally one ANS and it is the integrated activity of all of its components in association with the somatic nervous system and neuroendocrine system that is indispensable to homeostasis and survival.
A summary of the actions of the autonomic nervous system can be found at: Merck Manuals.
Anatomy of the ANS
The parasympathetic and sympathetic nervous systems each consist of two nerves – a preganglionic nerve which has its cell body within the CNS; and a postganglionic nerve which innervates the effector tissue. Shown in schematically in Figure 2 below.
Preganglionic nerves of the sympathetic nervous system leave the CNS in the thoracolumbar regions of the spinal cord and synapse with the postganglionic fibres in prevertebral and paravertebral ganglia adjacent to the spinal cord. The long postganglionic fibres run from these ganglia to the effector organs.
The parasympathetic preganglionic nerve fibres exit the spinal cord via the cranial nerves and the sacral regions of the spinal cord. The parasympathetic ganglia are located within the effector organs and the postganglionic fibres of the parasympathetic nervous system are, therefore, much shorter than those of the sympathetic system.
Elizabeth Davis, John Peters
This 23 slide Powerpoint presentation is intended to introduce the reader to the function of the autonomic nervous system (ANS). Specific areas that are covered include: the basic organization of the motor ANS and its components; the sympathetic and parasympathetic outflows from the central nervous system (CNS) to peripheral organs: the basics of neurochemical neurotransmission within the motor ANS including key neurotransmitters and receptor types; important selected activities of the motor ANS and finally some misconceptions regarding the ANS that even the beginner should be aware of.