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A somatic state which develops after chronic administration of certain drugs. The dependent state is characterized by the necessity to continue administration of the drug in order to avoid the appearance of uncomfortable or dangerous (withdrawal) symptoms.

desensitization (desensitisation)

A reduction in response to an agonist while it is continuously present at the receptor, or progressive decrease in response upon repeated exposure to an agonist.


A drug is a medicine or other substance which has a physiological effect when introduced into the body; a substance used in the diagnosis, treatment, or prevention of a disease or as a component of a medication.


An abnormal or disordered state of the body or of a bodily part. For example, blood dyscrasia is a pathological condition in which any of the components of the blood (usually cellular components) are abnormal in structure, function, or quality, as in leukemia or hemophilia.


Dystonia is a state of abnormal muscle tone resulting in muscular spasm and abnormal posture. Dystonia typically results from neurological disease or can be a side effect of certain drugs.

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