by jmundell@parthenonmgmt.com | Oct 7, 2025 | Pharmacology
Drug distribution is the process of delivering a drug from the bloodstream to the tissues of the body – especially the tissue(s) where its actions are needed. Open All Introduction to Drug Distribution The process of transferring a drug from the bloodstream to tissues...
by jmundell@parthenonmgmt.com | Oct 7, 2025 | Pharmacology
Before drugs can be clinically effective, they must be absorbed. Absorption is the process of a drug moving from its site of delivery into the bloodstream. The chemical composition of a drug, as well as the environment into which a drug is placed, work together to...
by jmundell@parthenonmgmt.com | Oct 7, 2025 | Pharmacology
When the relation between drug dose (X-axis) and drug response (Y-axis) is plotted on a linear scale, the resulting curve is usually hyperbolic. Clinical responses that might be plotted in this way include change in heart rate, blood pressure, gastric pH or blood...
by jmundell@parthenonmgmt.com | Oct 7, 2025 | Pharmacology
Open All Desensitization Desensitization refers to the common situation where the biological response to a drug diminishes when it is given continuously or repeatedly. It may be possible to restore the response by increasing the dose (or concentration) of the drug...
by jmundell@parthenonmgmt.com | Oct 7, 2025 | Pharmacology
There is wide variation in the structure and function of the different types of endogenous molecules which act as signal transmitters, from tiny gasses such as nitric oxide and carbon monoxide (sometimes referred to collectively as gasotransmitters), through...
by jmundell@parthenonmgmt.com | Oct 7, 2025 | Pharmacology
Endogenous peptides and proteins include well characterized families of neuropeptide transmitters, neuropeptide modulators, hormones, and fragments of functional proteins, which are essential in many biological processes. The peptides exert potent biological actions...
